SMYD1 Gene Summary [Human]
Predicted to enable histone-lysine N-methyltransferase activity. Involved in positive regulation of myoblast differentiation and positive regulation of myotube differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SMYD1 |
| Official Name | SET and MYND domain containing 1 [Source:HGNC Symbol;Acc:HGNC:20986] |
| Ensembl ID | ENSG00000115593 |
| Bio databases IDs | |
| Aliases | SET and MYND domain containing 1 |
| Synonyms | 4632404M21Rik, BOP, KMT3D, SET and MYND domain containing 1, ZMYND18, ZMYND22 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SMYD1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- MYND finger
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
- transcription co-repressor
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- hypoplasia
- growth failure
- single ventricle defect
role in cell
- expression in
- apoptosis
- differentiation
- maturation
- remodeling
- transactivation in
- state 3 respiration in
- mitochondrial respiration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SMYD1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- chromatin remodeling
- skeletal muscle cell differentiation
- negative regulation of transcription, DNA-dependent
- positive regulation of myotube differentiation
- positive regulation of myoblast differentiation
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding
- transcription corepressor activity