GPR26 Gene Summary [Human]

This gene encodes a G protein-couple receptor protein. G-protein-coupled receptors are a large family of membrane proteins that are involved in cellular responses to environmental stimuli, neurotransmitters, and hormones. The encoded protein may play a role in neurodegenerative diseases. Epigenetic silencing of this gene has been observed in gliomas. [provided by RefSeq, Sep 2016]

Details

Type
Protein Coding
Official Symbol
GPR26
Official Name
G protein-coupled receptor 26 [Source:HGNC Symbol;Acc:HGNC:4481]
Ensembl ID
ENSG00000154478
Bio databases IDs NCBI: 2849 Ensembl: ENSG00000154478
Aliases G protein-coupled receptor 26
Synonyms 9630036A11Rik, A730021D22, DKFZP761H2121, G protein-coupled receptor 26
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GPR26 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • G-protein coupled receptor
  • 7 transmembrane receptor (rhodopsin family)
  • seven-transmembrane G protein-coupled receptor superfamily

Pathways

Biological processes and signaling networks where the GPR26 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • Parkinson disease
  • acute myeloid leukemia
  • non-insulin-dependent diabetes mellitus
  • pervasive developmental disorder
  • diabetic nephropathy
  • Huntington disease
regulated by
  • beta-estradiol
  • honokiol
regulates

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cellular membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human GPR26 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway

Cellular Component

Where in the cell the gene product is active
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • G-protein coupled receptor activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.