CHODL Gene Summary [Human]
This gene encodes a type I membrane protein with a carbohydrate recognition domain characteristic of C-type lectins in its extracellular portion. In other proteins, this domain is involved in endocytosis of glycoproteins and exogenous sugar-bearing pathogens. This protein localizes predominantly to the perinuclear region. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Details
| Type | Protein Coding |
| Official Symbol | CHODL |
| Official Name | chondrolectin [Source:HGNC Symbol;Acc:HGNC:17807] |
| Ensembl ID | ENSG00000154645 |
| Bio databases IDs | |
| Aliases | chondrolectin |
| Synonyms | 3110074E07Rik, C21orf68, Chondrolectin, MT75, PRED12 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CHODL often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Lectin C-type domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- major depression
- cataract
- rheumatic carditis
- idiopathic scoliosis
- neuroblastoma
- neuroblastoma formation
- aortic valve calcification
- sporadic amyotrophic lateral sclerosis
- bulimia nervosa
role in cell
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- perinuclear region
- cellular membrane
- centrosome
- ER-to-Golgi intermediate compartment
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CHODL gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- positive regulation of axonogenesis
- nervous system development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- centrosome
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- hyaluronic acid binding
- carbohydrate binding