RRAGB Gene Summary [Human]
Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | RRAGB |
| Official Name | Ras related GTP binding B [Source:HGNC Symbol;Acc:HGNC:19901] |
| Ensembl ID | ENSG00000083750 |
| Bio databases IDs | |
| Aliases | Ras related GTP binding B |
| Synonyms | bA465E19.1, LOC100909655, LOC108348096, MGC69750, RAGB, Ras-related GTP binding B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RRAGB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Gtr1/RagA G protein conserved region
- nucleotide binding
- Ras family
- enzyme binding
- enzyme
- protein binding
- purine nucleotide binding
- GTP binding
- binding protein
- guanyl nucleotide binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by HIV-1
role in cell
- expression in
- proliferation
- phosphorylation in
- activation in
- differentiation
- cellular infiltration by
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- lysosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RRAGB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to amino acid stimulus
- cellular response to amino acid starvation
- negative regulation of autophagy
- protein localization
- cellular response to starvation
- positive regulation of TOR signaling cascade
- regulation of TOR signaling cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- guanyl ribonucleotide binding
- GTPase activity
- GTPase binding