NIFK Gene Summary [Human]
This gene encodes a protein that interacts with the forkhead-associated domain of the Ki-67 antigen. The encoded protein may bind RNA and may play a role in mitosis and cell cycle progression. Multiple pseudogenes exist on chromosomes 5, 10, 12, 15, and 19.[provided by RefSeq, Jan 2009]
Details
| Type | Protein Coding |
| Official Symbol | NIFK |
| Official Name | nucleolar protein interacting with the FHA domain of MKI67 [Source:HGNC Symbol;Acc:HGNC:17838] |
| Ensembl ID | ENSG00000155438 |
| Bio databases IDs | |
| Aliases | nucleolar protein interacting with the FHA domain of MKI67, nucleolar protein interacting with the FHA domain of pKi-67 |
| Synonyms | C130020J04Rik, LOC246042, MKI67IP, Nopp34, nucleolar protein interacting with the FHA domain of MKI67 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NIFK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- FHA Ki67 binding domain of hNIFK
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- chromosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NIFK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- rRNA metabolic process
- macromolecular complex assembly
- rRNA transcription
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- chromosome
- nucleolus
- nucleoplasm
- condensed nuclear chromosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding