TCF7L2 Gene Summary [Human]
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
Details
| Type | Protein Coding |
| Official Symbol | TCF7L2 |
| Official Name | transcription factor 7 like 2 [Source:HGNC Symbol;Acc:HGNC:11641] |
| Ensembl ID | ENSG00000148737 |
| Bio databases IDs | |
| Aliases | transcription factor 7 like 2 |
| Synonyms | LOC108348158, LOC683733, TCF-4, TCF4B, TCF4E, transcription factor 7 like 2, transcription factor 7 like 2, T cell specific, HMG box |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TCF7L2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-catenin binding domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- ligand-dependent nuclear receptor interactor
- protein kinase binding
- DNA binding domain
- nucleic acid binding
- beta-catenin binding
- high mobility group (HMG)-box domain superfamily
- transcription factor binding
- chromatin binding
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- gamma-catenin binding
- double-stranded DNA binding
- N-terminal CTNNB1 binding
- HMG (high mobility group) box
- HMG-box domain
- high mobility group
- catenin binding domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the TCF7L2 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Acute Myeloid Leukemia Signaling
- Basal Cell Carcinoma Signaling
- Chronic Myeloid Leukemia Signaling
- Colorectal Cancer Metastasis Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Epithelial Adherens Junction Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Molecular Mechanisms of Cancer
- Mouse Embryonic Stem Cell Pluripotency
- Opioid Signaling Pathway
- Osteoarthritis Pathway
- Ovarian Cancer Signaling
- PEDF Signaling
- Polyamine Regulation in Colon Cancer
- Protein Kinase A Signaling
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- T Cell Receptor Signaling
- Thyroid Cancer Signaling
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- non-insulin-dependent diabetes mellitus
- epithelial cancer
- bipolar disorder
- proteinuria
- hyperlipidemia
- COVID-19
- prostate cancer
- liver cancer
- multiple sclerosis
role in cell
- expression in
- proliferation
- survival
- migration
- differentiation
- apoptosis
- growth
- production in
- loss
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TCF7L2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein binding
- regulation of hormone metabolic process
- negative regulation of gluconeogenesis
- fat cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of epithelial to mesenchymal transition
- negative regulation of transcription from RNA polymerase II promoter
- regulation of smooth muscle cell proliferation
- response to glucose stimulus
- blood vessel development
- maintenance of DNA repeat elements
- negative regulation of transcription, DNA-dependent
- negative regulation of type B pancreatic cell apoptotic process
- canonical Wnt receptor signaling pathway
- positive regulation of insulin secretion
- positive regulation of epithelial cell proliferation
- pancreas development
- positive regulation of protein localization to nucleus
- myoblast cell fate commitment
- negative regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of heparan sulfate proteoglycan biosynthetic process
- regulation of transcription from RNA polymerase II promoter
- negative regulation of canonical Wnt receptor signaling pathway
- glucose homeostasis
- negative regulation of extrinsic apoptotic signaling pathway
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- PML body
- protein-DNA complex
- beta-catenin-TCF7L2 complex
- catenin-TCF7L2 complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- gamma-catenin binding
- protein kinase binding
- sequence-specific DNA binding transcription factor activity
- ligand-dependent nuclear receptor binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- armadillo repeat domain binding
- transcription regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- beta-catenin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity