SLC28A1 Gene Summary [Human]
Enables azole transmembrane transporter activity; cytidine transmembrane transporter activity; and uridine transmembrane transporter activity. Involved in azole transmembrane transport; nucleoside transport; and pyrimidine-containing compound transmembrane transport. Located in cytosol; nuclear speck; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SLC28A1 |
| Official Name | solute carrier family 28 member 1 [Source:HGNC Symbol;Acc:HGNC:11001] |
| Ensembl ID | ENSG00000156222 |
| Bio databases IDs | |
| Aliases | solute carrier family 28 member 1 |
| Synonyms | CNT1, CYP4B2, HCNT1, solute carrier family 28 member 1, solute carrier family 28 (sodium-coupled nucleoside transporter), member 1, URCTU |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC28A1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- uridine transporter
- cytidine transporter
- nucleoside transporter
- Nucleoside recognition
- pyrimidine- and adenine-specific:sodium symporter
- transmembrane domain
- pyrimidine transporter
- Na+ dependent nucleoside transporter C-terminus
- Na+ dependent nucleoside transporter N-terminus
- transporter
- nucleoside:sodium symporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- caffeine
disease
- Alzheimer disease
- neutropenia
- uridine-cytidineuria
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- thrombocytopenia
- colorectal carcinoma
- colorectal carcinomagenesis
- cerebral amyloid angiopathy
regulates
- uridine
- mizoribine
- pyrimidine nucleoside
- doxifluridine
- 5-fluorouridine
- gemcitabine
- nicotine
- pyrimidine base
- deoxyuridine
- nucleoside
role in cell
- cell death
- cell viability
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- cytosol
- apical membrane
- basolateral membrane
- nuclear speckles
- early endosomes
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC28A1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- uridine transport
- cytidine transport
- pyrimidine-containing compound transmembrane transport
- pyrimidine base transport
- azole transport
Cellular Component
Where in the cell the gene product is active
- brush border membrane
- nuclear speck
- cytosol
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- nucleoside:sodium symporter activity
- pyrimidine- and adenine-specific:sodium symporter activity
- uridine transmembrane transporter activity
- cytidine transmembrane transporter activity
- purine base transmembrane transporter activity