NCOR1 Gene Summary [Human]
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]
Details
| Type | Protein Coding |
| Official Symbol | NCOR1 |
| Official Name | nuclear receptor corepressor 1 [Source:HGNC Symbol;Acc:HGNC:7672] |
| Ensembl ID | ENSG00000141027 |
| Bio databases IDs | |
| Aliases | nuclear receptor corepressor 1, thyroid hormone- and retinoic acid receptor-associated corepressor 1, protein phosphatase 1, regulatory subunit 109 |
| Synonyms | 5730405M06RIK, A230020K14RIK, hN-CoR, mKIAA1047, N-CoR, nuclear receptor co-repressor 1, PPP1R109, RIP13, Rxrip13, TRAC1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NCOR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone deacetylase regulator
- RD rich domain
- transcription regulator
- LXXLL motif
- retinoic acid receptor binding
- transcription co-repressor
- deacetylase motif
- transcription factor binding
- coiled-coil domain
- chromatin binding
- estrogen receptor binding
- glutamine-rich domain
- receptor binding domain
- peroxisome proliferator activated receptor binding
- Myb-like DNA-binding domain
- CoRNR motif
- binding domain
- SANT
- nuclear receptor domain
- ligand-dependent nuclear receptor interactor
- SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
- nucleic acid binding
- Sin3 binding domain
- alpha helix
- histone deacetylase binding
- protein domain specific binding
- protein binding
- thyroid hormone receptor binding
- sequence-specific DNA binding
- G-protein pathway suppressor 2-interacting domain
- DNA binding
- protein binding domain
- transcription repression domain
- double-stranded DNA binding
- histone deacetylase binding domain
- retinoid X receptor binding
Pathways
Biological processes and signaling networks where the NCOR1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- precursor B-cell acute lymphoblastic leukemia
- metastasis
- neoplasia
- cholangiocarcinoma cancer
- bile duct cancer
- biliary tract cancer
- epithelial cancer
- pancreaticobiliary cancer
- epithelial neoplasia
- cancer
role in cell
- expression in
- proliferation
- growth
- inhibition in
- quantity
- binding in
- number
- repression in
- transcription in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- heterochromatin
- Cytoplasm
- perinuclear region
- cytosol
- nucleoplasm
- mitotic spindle
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NCOR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- spindle assembly
- negative regulation of transcription, DNA-dependent
- locomotor rhythm
- negative regulation of glycolysis
- chromatin organization
- negative regulation of JNK cascade
- negative regulation of fatty acid metabolic process
- negative regulation of androgen receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitotic spindle
- transcriptional repressor complex
- membrane
- histone deacetylase complex
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ligand-dependent nuclear receptor binding
- protein binding
- histone deacetylase binding
- transcription corepressor activity
- transcription regulatory region sequence-specific DNA binding
- thyroid hormone receptor binding