NCOR2 Gene Summary [Human]
This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]
Details
| Type | Protein Coding |
| Official Symbol | NCOR2 |
| Official Name | nuclear receptor corepressor 2 [Source:HGNC Symbol;Acc:HGNC:7673] |
| Ensembl ID | ENSG00000196498 |
| Bio databases IDs | |
| Aliases | nuclear receptor corepressor 2, silencing mediator of retinoic acid and thyroid hormone receptor, CTG repeat protein 26, thyroid-, retinoic-acid-receptor-associated corepressor |
| Synonyms | CTG26, N-CoR, nuclear receptor co-repressor 2, RETINOID SILENCER, SMAP270, SMRT, SMRTE, SMRTE-tau, TNRC14, TRAC, TRAC-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NCOR2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- silencing domain
- transcription regulator
- ID domain
- retinoic acid receptor binding
- transcription co-repressor
- chromatin binding
- glutamine-rich domain
- enzyme activator activity
- deacetylase activating domain
- receptor binding domain
- Myb-like DNA-binding domain
- CoRNR motif
- Smrt repression domain
- SANT
- nuclear receptor domain
- ligand-dependent nuclear receptor interactor
- SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
- BCL6-binding domain
- Cbf1/rbp-jk interaction domain
- alpha helix
- histone deacetylase binding
- protein binding
- sequence-specific DNA binding
- Eto binding domain
- G-protein pathway suppressor 2-interacting domain
- DNA binding
- transcription repression domain
- binding protein
- Trichohyalin-plectin-homology domain
- double-stranded DNA binding
- Ras/Rap binding domain
- retinoid X receptor binding
- glycine serine rich domain
- notch binding
Pathways
Biological processes and signaling networks where the NCOR2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- metastasis
- hypertension
- atrial fibrillation
- schizophrenia
- multiple sclerosis
- liver cancer
- epithelial cancer
- non-insulin-dependent diabetes mellitus
- respiratory distress syndrome
role in cell
- expression in
- apoptosis
- number
- quantity
- proliferation
- lipolysis in
- phosphorylation in
- migration
- invasion by
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nuclear foci
- MAD bodies
- nucleoplasm
- nuclear bodies
- nuclear speckles
- nuclear matrix
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NCOR2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- cerebellum development
- response to estradiol stimulus
- lactation
- response to organic nitrogen
- regulation of cellular ketone metabolic process
- negative regulation of androgen receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- transcriptional repressor complex
- membrane
- nuclear matrix
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- histone deacetylase binding
- transcription corepressor activity
- Notch binding
- chromatin binding
- glucocorticoid receptor binding
- retinoid X receptor binding