SPPL3 Gene Summary [Human]
Enables aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Involved in several processes, including T cell receptor signaling pathway; positive regulation of calcineurin-NFAT signaling cascade; and positive regulation of protein dephosphorylation. Located in Golgi-associated vesicle membrane; plasma membrane; and rough endoplasmic reticulum. Is integral component of cytoplasmic side of endoplasmic reticulum membrane and integral component of lumenal side of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SPPL3 |
| Official Name | signal peptide peptidase like 3 [Source:HGNC Symbol;Acc:HGNC:30424] |
| Ensembl ID | ENSG00000157837 |
| Bio databases IDs | |
| Aliases | signal peptide peptidase like 3, intramembrane protease 2, presenilin-like protein 4 |
| Synonyms | 4833416I09RIK, IMP2, MDHV1887, PRO4332, PSH1, PSL4, RGD1562826, signal peptide peptidase 3, signal peptide peptidase like 3, Sppl3-ps1, USMG3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SPPL3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- aspartic endopeptidase, intramembrane cleaving
- peptidase
- protein homodimerization
- protein binding
- Signal peptide peptidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- depressive disorder
- major depression
- non-insulin-dependent diabetes mellitus
- coronary artery disease
- asthma
- colorectal cancer
- refractive error
- systemic lupus erythematosus
- allergy
- alcoholic liver disease
regulates
role in cell
- number
- lysis
- killing
- trogocytosis
- elevation in
- cytotoxicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- Plasma Membrane
- Golgi membrane
- rough endoplasmatic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SPPL3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein binding
- membrane protein ectodomain proteolysis
- membrane protein proteolysis
- positive regulation of calcineurin-NFAT signaling cascade
- signal peptide processing
- positive regulation of protein dephosphorylation
- T cell receptor signaling pathway
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- membrane
- Golgi-associated vesicle membrane
- rough endoplasmic reticulum
- Golgi apparatus
- plasma membrane
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- aspartic endopeptidase activity, intramembrane cleaving