RER1 Gene Summary [Human]
The protein encoded by this gene is a multi-pass membrane protein that is localized to the golgi apparatus. It is involved in the retention of endoplasmic reticulum (ER) membrane proteins in the ER and retrieval of ER membrane proteins from the early Golgi compartment to facilitate gamma-secretase complex assembly. [provided by RefSeq, Oct 2009]
Details
| Type | Protein Coding |
| Official Symbol | RER1 |
| Official Name | retention in endoplasmic reticulum sorting receptor 1 [Source:HGNC Symbol;Acc:HGNC:30309] |
| Ensembl ID | ENSG00000157916 |
| Bio databases IDs | |
| Aliases | retention in endoplasmic reticulum sorting receptor 1 |
| Synonyms | 1110060F11Rik, 5830454N22Rik, retention in endoplasmic reticulum sorting receptor 1, RGD1306324 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RER1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rer1 family
- protein binding
- receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
role in cell
- expression in
- cell viability
- accumulation in
- transmembrane potential
- development
- mitochondrial fission in
- trafficking in
- degradation in
- area
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- Golgi Apparatus
- Endoplasmic Reticulum
- ER-to-Golgi intermediate compartment
- endoplasmic reticulum membrane
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RER1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal muscle acetylcholine-gated channel clustering
- retrograde vesicle-mediated transport, Golgi to ER
- protein retention in ER lumen
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- Golgi apparatus
- Golgi membrane
- endoplasmic reticulum-Golgi intermediate compartment
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- acetylcholine receptor binding