Rer1 Gene Summary [Rat]
Predicted to enable acetylcholine receptor binding activity. Predicted to be involved in protein retention in ER lumen and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within positive regulation of protein localization to plasma membrane and skeletal muscle acetylcholine-gated channel clustering. Predicted to be located in Golgi apparatus; cell surface; and endoplasmic reticulum-Golgi intermediate compartment. Predicted to be active in Golgi membrane. Orthologous to human RER1 (retention in endoplasmic reticulum sorting receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rer1 |
| Official Name | retention in endoplasmic reticulum sorting receptor 1 [Source:RGD Symbol;Acc:1306324] |
| Ensembl ID | ENSRNOG00000014270 |
| Bio databases IDs | |
| Aliases | retention in endoplasmic reticulum sorting receptor 1 |
| Synonyms | 1110060F11Rik, 5830454N22Rik, retention in endoplasmic reticulum sorting receptor 1, RGD1306324 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rer1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rer1 family
- protein binding
- receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
role in cell
- expression in
- cell viability
- accumulation in
- transmembrane potential
- development
- mitochondrial fission in
- trafficking in
- degradation in
- area
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- Golgi Apparatus
- Endoplasmic Reticulum
- ER-to-Golgi intermediate compartment
- endoplasmic reticulum membrane
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rer1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal muscle acetylcholine-gated channel clustering
- retrograde vesicle-mediated transport, Golgi to ER
- protein retention in ER lumen
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- Golgi apparatus
- Golgi membrane
- endoplasmic reticulum-Golgi intermediate compartment
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- acetylcholine receptor binding