CYP4A22 Gene Summary [Human]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Details

Type
Processed Transcript
Official Symbol
CYP4A22
Official Name
cytochrome P450 family 4 subfamily A member 22 [Source:HGNC Symbol;Acc:HGNC:20575]
Ensembl ID
ENSG00000162365
Bio databases IDs NCBI: 284541 Ensembl: ENSG00000162365
Aliases cytochrome P450 family 4 subfamily A member 22
Synonyms cytochrome P450 family 4 subfamily A member 22
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CYP4A22 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • cytochrome P450 (CYP) superfamily
  • Cytochrome P450
  • CH-OH group:NAD or NADP oxidoreductase
  • enzyme

Pathways

Biological processes and signaling networks where the CYP4A22 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • chronic obstructive pulmonary disease
  • epithelial cancer
  • liver cancer
  • hepatocellular carcinoma

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human CYP4A22 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • lauric acid metabolic process
  • omega-hydroxylase P450 pathway
  • kidney development
  • lipid hydroxylation
  • linoleic acid metabolic process
  • icosanoid biosynthetic process
  • arachidonic acid metabolic process

Cellular Component

Where in the cell the gene product is active
  • endoplasmic reticulum membrane
  • extracellular space
  • intracellular membrane-bounded organelle

Molecular Function

What the gene product does at the molecular level
  • arachidonic acid monooxygenase activity
  • iron ion binding
  • arachidonic acid omega-hydroxylase activity
  • alkane 1-monooxygenase activity
  • heme binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.