NTNG1 Gene Summary [Human]

This gene encodes a preproprotein that is processed into a secreted protein containing eukaroytic growth factor (EGF)-like domains. This protein acts to guide axon growth during neuronal development. Polymorphisms in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2015]

Details

Type
Protein Coding
Official Symbol
NTNG1
Official Name
netrin G1 [Source:HGNC Symbol;Acc:HGNC:23319]
Ensembl ID
ENSG00000162631
Bio databases IDs NCBI: 22854 Ensembl: ENSG00000162631
Aliases netrin G1, netrin G1f, Netrin-G1
Synonyms A930010C08RIK, KIAA0976, Laminet-1, Lmnt1, LOC102724829, NetG1, NETRIN G1, RGD1563465
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NTNG1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Laminin-type epidermal growth factor-like domai
  • Laminin N-terminal (Domain VI)
  • cell adhesion molecule binding
  • protein binding
  • EGF_CA
  • Laminin EGF domain

Pathways

Biological processes and signaling networks where the NTNG1 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • metabolic syndrome X
  • COVID-19
  • anorexia nervosa
  • diabetic nephropathy
  • renal clear cell adenocarcinoma
  • renal clear cell cancer
  • non-insulin-dependent diabetes mellitus
  • complex neurodevelopmental disorder
  • pyogenic granuloma
  • capillary hemangioma formation
regulated by
regulates
role in cell
  • adhesion
  • development
  • migration by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space
  • glutaminergic synapse
  • cell surface
  • Plasma Membrane
  • presynaptic membrane
  • synapse

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human NTNG1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • axonogenesis
  • regulation of synaptic transmission
  • regulation of neuron projection development
  • regulation of neuron migration

Cellular Component

Where in the cell the gene product is active
  • presynaptic active zone membrane
  • extracellular region
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • cell adhesion molecule binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.