Ntng1 Gene Summary [Mouse]
Predicted to enable cell-cell adhesion mediator activity. Involved in several processes, including regulation of cell projection organization; regulation of neuron migration; and synaptic membrane adhesion. Acts upstream of or within axonogenesis. Located in plasma membrane. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and presynaptic active zone membrane. Is expressed in several structures, including brain and enteric nervous system. Orthologous to human NTNG1 (netrin G1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ntng1 |
| Official Name | netrin G1 [Source:MGI Symbol;Acc:MGI:1934028] |
| Ensembl ID | ENSMUSG00000059857 |
| Bio databases IDs | |
| Aliases | netrin G1 |
| Synonyms | A930010C08RIK, KIAA0976, Laminet-1, Lmnt1, LOC102724829, NetG1, NETRIN G1, RGD1563465 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ntng1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Laminin-type epidermal growth factor-like domai
- Laminin N-terminal (Domain VI)
- cell adhesion molecule binding
- protein binding
- EGF_CA
- Laminin EGF domain
Pathways
Biological processes and signaling networks where the Ntng1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- COVID-19
- anorexia nervosa
- diabetic nephropathy
- renal clear cell adenocarcinoma
- renal clear cell cancer
- non-insulin-dependent diabetes mellitus
- complex neurodevelopmental disorder
- pyogenic granuloma
- capillary hemangioma formation
regulates
role in cell
- adhesion
- development
- migration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- cell surface
- Plasma Membrane
- presynaptic membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ntng1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- axonogenesis
- regulation of synaptic transmission
- regulation of neuron projection development
- regulation of neuron migration
Cellular Component
Where in the cell the gene product is active
- presynaptic active zone membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cell adhesion molecule binding