TRIM46 Gene Summary [Human]
This gene encodes a protein of the tripartite motif (TRIM) family. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. TRIM46 is reported to be involved in the proliferation of multiple types of cancer cells including lung and breast cancer. It has also been shown to control neuronal polarity and axon specification by forming uniform microtubule bundles in the axon. [provided by RefSeq, May 2022]
Details
| Type | Protein Coding |
| Official Symbol | TRIM46 |
| Official Name | tripartite motif containing 46 [Source:HGNC Symbol;Acc:HGNC:19019] |
| Ensembl ID | ENSG00000163462 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 46 |
| Synonyms | AI385631, GENEY, LOC100912251, LOC103690106, TRIFIC, tripartite motif-containing 46 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM46 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- microtubule binding
- B-box-type zinc finger superfamily
- B-Box C-terminal domain
- SPRY domain
- RING-type zinc-finger
- FN3
- Ring finger
- B-box zinc finger
- TRIM C-terminal subgroup One Signature domain
- Fibronectin type 3 domain
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- axon component
- microtubules
- neurites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM46 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron migration
- microtubule bundle formation
- regulation of protein localization
- negative regulation of axon extension
- axonogenesis
- anterograde synaptic vesicle transport
Cellular Component
Where in the cell the gene product is active
- initial segment
- cytoskeleton
- main axon
Molecular Function
What the gene product does at the molecular level
- zinc ion binding