MTNR1B Gene Summary [Human]
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MTNR1B |
| Official Name | melatonin receptor 1B [Source:HGNC Symbol;Acc:HGNC:7464] |
| Ensembl ID | ENSG00000134640 |
| Bio databases IDs | |
| Aliases | melatonin receptor 1B |
| Synonyms | FGQTL2, Mel1b, MEL-1B-R, melatonin receptor 1B, MT2, MT2 receptor |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MTNR1B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- melatonin receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the MTNR1B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- Parkinson disease
- Alzheimer disease
- fatigue
- major depression
- insomnia
- susceptibility to type 2 diabetes mellitus
- traumatic brain injury
- attention deficit hyperactivity disorder
- cognitive impairment
role in cell
- expression in
- apoptosis
- plasticity
- long-term potentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MTNR1B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- negative regulation of vasoconstriction
- synaptic transmission
- reduction of cytosolic calcium ion concentration
- negative regulation of insulin secretion
- negative regulation of neuron apoptotic process
- positive regulation of circadian sleep/wake cycle, non-REM sleep
- regulation of insulin secretion
- negative regulation of transmission of nerve impulse
- positive regulation of transmission of nerve impulse
- camera-type eye development
- glucose homeostasis
- negative regulation of cGMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- melatonin receptor activity