RNF125 Gene Summary [Human]
This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway. [provided by RefSeq, Mar 2012]
Details
| Type | Protein Coding |
| Official Symbol | RNF125 |
| Official Name | ring finger protein 125 [Source:HGNC Symbol;Acc:HGNC:21150] |
| Ensembl ID | ENSG00000101695 |
| Bio databases IDs | |
| Aliases | ring finger protein 125 |
| Synonyms | 4930553F04RIK, C730049O14Rik, FLJ20456, ring finger protein 125, TNORS, TRAC1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNF125 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- enzyme binding
- enzyme
- p53 binding
- Ring finger domain
- protein binding
- C2HC Zing finger domain
- zinc ion binding
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- metastasis
- Alzheimer disease
- Tenorio syndrome
- organismal death
- chronic lymphocytic leukemia
- androgenic alopecia
role in cell
- expression in
- phosphorylation in
- migration
- proliferation
- invasion by
- ubiquitination in
- conjugation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNF125 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of type I interferon production
- protein polyubiquitination
- adaptive immune response
- negative regulation of RIG-I signaling pathway
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- Cdc48p-Npl4p-Ufd1p AAA ATPase complex
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- p53 binding
- ubiquitin conjugating enzyme binding
- zinc ion binding
- protein binding