ADORA1 Gene Summary [Human]
The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ADORA1 |
| Official Name | adenosine A1 receptor [Source:HGNC Symbol;Acc:HGNC:262] |
| Ensembl ID | ENSG00000163485 |
| Bio databases IDs | |
| Aliases | adenosine A1 receptor |
| Synonyms | A1-AR, A1R, AA1R, Ad1, ADENOSINE A1 receptor, AI848715, ARA1, RDC7, Ri |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADORA1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- third intracellular loop
- G-protein coupled adenosine receptor
- binding protein
- heat shock protein binding
- G-protein-coupled receptor binding
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- protein heterodimerization
Pathways
Biological processes and signaling networks where the ADORA1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ADRB1
- AMP-579
- VER-7146
- 8-isopropyl-2,6-diphenyl-9H-purine
- neurabin
- CGS 24012
- 9-chloro-2-(2-furanyl)-5-[(trimethylacetyl)amino][1,2,4]-triazolo[1,5-c]quinazoline
- N-(3-phenyl-1,2,4-thiadiazol-5-yl)-4-hydroxybenzamide
- 8-bromo-9-ethyladenine
- 8-cyclopentyl-1,3-dipropylxanthine
disease
- precursor B-cell acute lymphoblastic leukemia
- acute myeloid leukemia
- relapsed acute lymphocytic leukemia
- acute lymphoblastic lymphoma
- relapsed acute myeloid leukemia
- myelodysplastic syndrome
- glioblastoma
- treatment-related acute myeloid leukemia
- T acute lymphoblastic leukemia
- heart failure
role in cell
- activation in
- expression in
- apoptosis
- migration
- activation
- binding in
- production in
- cell viability
- morphology
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- caveolae fraction
- membrane fraction
- intracellular structures
- Cytoplasm
- presynaptic regions
- cilia
- cell surface
- Extracellular Space
- apical compartment
- perinuclear region
- postsynaptic region
- cellular membrane
- Endoplasmic Reticulum
- presynaptic membrane
- postsynaptic membrane
- caveolae
- basolateral membrane
- dendritic spines
- axonal membrane
- nerve ending
- synaptosomes
- synapse
- membrane rafts
- membrane processes
- perikaryon
- axons
- dendrites
- axon terminals
- presynaptic terminals
- postsynaptic terminals
- dendritic branches
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ADORA1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of glomerular filtration
- negative regulation of long term synaptic depression
- positive regulation of potassium ion transport
- regulation of respiratory gaseous exchange by neurological system process
- inflammatory response
- response to hypoxia
- negative regulation of synaptic transmission, glutamatergic
- positive regulation of nucleoside transport
- long term synaptic depression
- triglyceride homeostasis
- negative regulation of lipid catabolic process
- positive regulation of lipid catabolic process
- regulation of excitatory postsynaptic membrane potential
- G-protein coupled receptor signaling pathway
- regulation of cardiac muscle cell contraction
- response to purine-containing compound
- cell-cell signaling
- protein targeting to membrane
- negative regulation of leukocyte migration
- lipid catabolic process
- positive regulation of protein dephosphorylation
- detection of temperature stimulus involved in sensory perception of pain
- regulation of sensory perception of pain
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- negative regulation of long-term synaptic potentiation
- negative regulation of cell proliferation
- nervous system development
- apoptotic signaling pathway
- vasodilation
- negative regulation of neurotrophin production
- negative regulation of synaptic transmission, GABAergic
- cognition
- signal transduction
- fatty acid homeostasis
- positive regulation of systemic arterial blood pressure
- negative regulation of systemic arterial blood pressure
- negative regulation of glutamate secretion
- positive regulation of MAPK cascade
- negative regulation of circadian sleep/wake cycle, non-REM sleep
- positive regulation of peptide secretion
- negative regulation of hormone secretion
- negative regulation of acute inflammatory response
- adenosine receptor signaling pathway
- mucus secretion
- negative regulation of apoptotic process
- temperature homeostasis
- phagocytosis
- negative regulation of mucus secretion
- leukocyte migration
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- synapse
- neuronal cell body
- plasma membrane
- calyx of Held
- dendrite
- presynaptic active zone
- terminal button
- postsynaptic membrane
- dendritic spine
- asymmetric synapse
- axolemma
- basolateral plasma membrane
Molecular Function
What the gene product does at the molecular level
- purine nucleoside binding
- heat shock protein binding
- G-protein coupled receptor binding
- protein binding
- protein heterodimerization activity
- heterotrimeric G-protein binding
- G-protein beta/gamma-subunit complex binding
- G-protein coupled adenosine receptor activity