CASP3
CASP3 Gene Summary
The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]
Details
| Type | Protein Coding |
| Official Symbol | CASP3 |
| Official Name | caspase 3 [Source:HGNC Symbol;Acc:HGNC:1504] |
| Ensembl ID | ENSG00000164305 |
| Bio databases IDs | |
| Aliases | caspase 3 |
| Synonyms | A830040C14Rik,AC-3,Caspase-3,CASPASE-3 p20,CC3,CPP-32,CPP32B,CPP32-beta,CPP32-β,Ice-like cysteine protease,Lice,mldy,SCA-1,YAMA |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- death receptor binding
- protease binding
- catalytic domain
- peptidase
- allosteric site
- enzyme
- protein binding
- phosphorylation site
- cyclin-dependent protein kinase inhibitor activity
- CASc
- phospholipase A2 activator
- endopeptidase
- cysteine-type peptidase
- cysteine endopeptidase
- binding protein
- p12 domain
- aspartic endopeptidase
- active site
- pro domain
- p17 domain
Pathways
Biological processes and signaling networks where the CASP3 gene plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Apoptosis Signaling
- CD27 Signaling in Lymphocytes
- Death Receptor Signaling
- DNA damage-induced 14-3-3σ Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Endoplasmic Reticulum Stress Pathway
- Endothelin-1 Signaling
- eNOS Signaling
- Granzyme B Signaling
- HER-2 Signaling in Breast Cancer
- Induction of Apoptosis by HIV1
- Inhibition of Angiogenesis by TSP1
- Lymphotoxin β Receptor Signaling
- Molecular Mechanisms of Cancer
- Myc Mediated Apoptosis Signaling
- PAK Signaling
- Parkinson's Signaling
- PTEN Signaling
- Retinoic acid Mediated Apoptosis Signaling
- Role of MAPK Signaling in the Pathogenesis of Influenza
- TNFR1 Signaling
- Tumoricidal Function of Hepatic Natural Killer Cells
- TWEAK Signaling
- UVA-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- MAP3K1
- CASP3
- NDUFS1
- MDM2
- NFKB1
- XIAP
- TRIM28
- RELA
- HSPD1
- PRKN
disease
- neoplasia
- metastasis
- lung adenocarcinoma
- cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
- microphthalmia
- diabetic retinopathy
- neurodegeneration
- Alzheimer disease
regulated by
- P glycoprotein
- diclofenac
- Scd1
- APP
- lysophosphatidylcholine
- arachidonic acid
- eicosapentaenoic acid
- singlet oxygen
- isoflurane
- secondhand smoke
regulates
- TNF
- BCL2L1
- NOS2
- TP53
- PPP1R12A
- CDKN1A
- STAT3
- BIRC5
- ERK1/2
- AKT
role in cell
- phosphorylation in
- number
- apoptosis
- cell viability
- expression in
- proliferation
- binding
- survival
- growth
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- intracellular space
- perinuclear region
- cellular membrane
- Nucleus
- centrosome
- Mitochondria
- granules
- cytosol
- mitochondrial intermembrane space
- nucleoplasm
- residual bodies
- membrane rafts
- membrane processes
- perikaryon
- axons
- dendrites
- postsynaptic density
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CASP3 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- learning or memory
- axonal fasciculation
- T cell homeostasis
- sensory perception of sound
- response to glucose stimulus
- response to hypoxia
- apoptotic process
- platelet formation
- protein maturation
- neuron apoptotic process
- glial cell apoptotic process
- neuron differentiation
- response to hydrogen peroxide
- response to DNA damage stimulus
- luteolysis
- keratinocyte differentiation
- nerve growth factor receptor signaling pathway
- induction of apoptosis by ionic changes
- erythrocyte differentiation
- regulation of macroautophagy
- response to estradiol stimulus
- leukocyte apoptotic process
- protein processing
- response to tumor necrosis factor
- response to X-ray
- response to amino acid stimulus
- response to wounding
- negative regulation of cell cycle
- apoptotic signaling pathway
- intrinsic apoptotic signaling pathway
- response to UV
- response to xenobiotic stimulus
- execution phase of apoptosis
- positive regulation of neuron apoptotic process
- heart development
- striated muscle cell differentiation
- negative regulation of B cell proliferation
- response to glucocorticoid stimulus
- pyroptosis
- response to cobalt ion
- protein catabolic process
- negative regulation of activated T cell proliferation
- hippocampus development
- fibroblast apoptotic process
- response to nicotine
- B cell homeostasis
- regulation of protein stability
- cell fate commitment
- proteolysis
- response to lipopolysaccharide
- negative regulation of cytokine production
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- death-inducing signaling complex
- neuronal cell body
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- aspartic-type endopeptidase activity
- cysteine-type endopeptidase activity
- death receptor binding
- protease binding
- enzyme activator activity
- peptidase activity
- cyclin-dependent protein kinase inhibitor activity
- cysteine-type endopeptidase activity involved in apoptotic process
- cysteine-type endopeptidase activity involved in apoptotic signaling pathway
- protein binding
- cysteine-type endopeptidase activity involved in execution phase of apoptosis
- phospholipase A2 activator activity