NLGN4Y Gene Summary [Human]
This gene encodes a type I membrane protein that belongs to the family of neuroligins, which are cell adhesion molecules present at the postsynaptic side of the synapse, and may be essential for the formation of functional synapses. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Mar 2011]
Details
| Type | Protein Coding |
| Official Symbol | NLGN4Y |
| Official Name | neuroligin 4 Y-linked [Source:HGNC Symbol;Acc:HGNC:15529] |
| Ensembl ID | ENSG00000165246 |
| Bio databases IDs | |
| Aliases | neuroligin 4 Y-linked |
| Synonyms | HNL4Y, neuroligin 4 Y-linked |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NLGN4Y often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Carboxylesterase family
- alpha/beta hydrolases
- cell adhesion molecule binding
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cellular membrane
- synapse
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NLGN4Y gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- social behavior
- postsynaptic membrane assembly
- synaptic vesicle endocytosis
- presynaptic membrane assembly
- regulation of synaptic transmission
- synaptic transmission
- neuron cell-cell adhesion
- learning
- vocalization behavior
Cellular Component
Where in the cell the gene product is active
- membrane
- synapse
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- scaffold protein binding
- protein binding
- cell adhesion molecule binding
- signaling receptor activity
- neurexin family protein binding