PRIM1 Gene Summary [Human]
The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the small, 49 kDa primase subunit. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PRIM1 |
| Official Name | DNA primase subunit 1 [Source:HGNC Symbol;Acc:HGNC:9369] |
| Ensembl ID | ENSG00000198056 |
| Bio databases IDs | |
| Aliases | DNA primase subunit 1 |
| Synonyms | DNA polymerase alpha subunit 4, DNA polymerase α subunit 4, DNA primase, p49 subunit, DNA primase subunit 1, LOC100362209, p48, p49, PDIL |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRIM1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleotide binding
- binding protein
- zinc ion binding
- DNA-directed RNA polymerase
- nucleotidyltransferase
- DNA primase small subunit
- AE_Prim_S_like
- enzyme
- protein binding
- magnesium ion binding
Pathways
Biological processes and signaling networks where the PRIM1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute lymphoblastic lymphoma
- diffuse large B-cell lymphoma
- mammary neoplasm
- cutaneous melanoma
- neoplasia
- T-cell/histiocyte rich large B-cell lymphoma
- primary mediastinal large B-cell lymphoma
- refractory chronic lymphocytic leukemia
- leg type primary cutaneous diffuse large B-cell lymphoma
- grade 3b follicular lymphoma
regulates
- RNA primer
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRIM1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA-dependent DNA replication initiation
- DNA replication, synthesis of RNA primer
Cellular Component
Where in the cell the gene product is active
- alpha DNA polymerase:primase complex
- membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- DNA primase activity
- zinc ion binding
- protein binding
- ribonucleotide binding