PRIM2 Gene Summary [Human]
This gene encodes the 58 kilodalton subunit of DNA primase, an enzyme that plays a key role in the replication of DNA. The encoded protein forms a heterodimer with a 49 kilodalton subunit. This heterodimer functions as a DNA-directed RNA polymerase to synthesize small RNA primers that are used to create Okazaki fragments on the lagging strand of the DNA. Alternative splicing of this gene results in multiple transcript variants. This gene has a related pseudogene, which is also present on chromosome 6. [provided by RefSeq, Apr 2014]
Details
| Type | Protein Coding |
| Official Symbol | PRIM2 |
| Official Name | DNA primase subunit 2 [Source:HGNC Symbol;Acc:HGNC:9370] |
| Ensembl ID | ENSG00000146143 |
| Bio databases IDs | |
| Aliases | DNA primase subunit 2 |
| Synonyms | DNA primase, p58 subunit, DNA primase subunit 2, p58, Pola3, PRIM2A, Primase large subunit |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRIM2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- Archaeal/eukaryotic core primase: Large subunit, PriL
- DNA-directed RNA polymerase
- nucleic acid binding
- nucleotidyltransferase
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the PRIM2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- neoplasia
- precursor B-cell acute lymphoblastic leukemia
- organismal death
- chronic phase chronic myeloid leukemia
- myeloid sarcoma
- acute lymphoblastic lymphoma
- diffuse large B-cell lymphoma transformed from follicular lymphoma
- relapsed acute myeloid leukemia
- unclassifiable B-cell lymphoma
regulates
- RNA primer
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRIM2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA-dependent DNA replication initiation
- DNA replication, synthesis of RNA primer
Cellular Component
Where in the cell the gene product is active
- alpha DNA polymerase:primase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding
- DNA/RNA hybrid binding
- 4 iron, 4 sulfur cluster binding