C15orf48 Gene Summary [Human]
This gene was first identified in a study of human esophageal squamous cell carcinoma tissues. Levels of both the message and protein are reduced in carcinoma samples. In adult human tissues, this gene is expressed in the the esophagus, stomach, small intestine, colon and placenta. Alternatively spliced transcript variants that encode the same protein have been identified. [provided by RefSeq, Jun 2012]
Details
| Type | Protein Coding |
| Official Symbol | C15orf48 |
| Official Name | chromosome 15 open reading frame 48 [Source:HGNC Symbol;Acc:HGNC:29898] |
| Ensembl ID | ENSG00000166920 |
| Bio databases IDs | |
| Aliases | chromosome 15 open reading frame 48, normal mucosa of esophagus specific 1, MIR147B host gene, cytochrome c oxidase subunit FA4 like 3, modulator of cytochrome C oxidase during inflammation, mitochondrial stress response antiviral |
| Synonyms | AA467197, C3h15orf48, chromosome 15 open reading frame 48, COXFA4L3, expressed sequence AA467197, FOAP-11, mir-147, MIR147BHG, MISTRAV, MOCCI, NMES1, similar to human chromosome 15 open reading frame 48 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human C15orf48 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- NADH-ubiquinone reductase complex 1 MLRQ subunit
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human C15orf48 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to bacterium
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial respiratory chain complex IV
Molecular Function
What the gene product does at the molecular level
- protein binding