TCEA2 Gene Summary [Human]
The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | TCEA2 |
| Official Name | transcription elongation factor A2 [Source:HGNC Symbol;Acc:HGNC:11614] |
| Ensembl ID | ENSG00000171703 |
| Bio databases IDs | |
| Aliases | transcription elongation factor A2 |
| Synonyms | S-II-T1, Tceat, Testis-specific S-II, TFIIS, transcription elongation factor A2, transcription elongation factor A (SII), 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TCEA2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Transcription factor S-II (TFIIS), central domain
- TFIIS helical bundle-like domain
- TFIIS_I
- Zn-ribbon
- protein binding
- transcription elongation factor S-II
- Transcription factor S-II M domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- basal bodies
- centrosome
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TCEA2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription, DNA-dependent
- regulation of transcription elongation, DNA-dependent
- transcription elongation, DNA-dependent
- transcription elongation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- transcription elongation factor complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- protein binding