SLCO2A1 Gene Summary [Human]
This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues. [provided by RefSeq, Dec 2011]
Details
| Type | Protein Coding |
| Official Symbol | SLCO2A1 |
| Official Name | solute carrier organic anion transporter family member 2A1 [Source:HGNC Symbol;Acc:HGNC:10955] |
| Ensembl ID | ENSG00000174640 |
| Bio databases IDs | |
| Aliases | solute carrier organic anion transporter family member 2A1 |
| Synonyms | 2310021C19Rik, MATR1, Matrin F/Q, OATP2A1, PGT, PHOAD, PHOAR2, SLC21A2, solute carrier organic anion transporter family member 2A1, solute carrier organic anion transporter family, member 2a1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLCO2A1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- Organic Anion Transporter Polypeptide (OATP) family
- Major Facilitator Superfamily
- sodium-independent organic anion transporter
- KAZAL_FS
- prostaglandin transporter
- transporter
Pathways
Biological processes and signaling networks where the SLCO2A1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- prostaglandin E2
- GRB2
disease
- colorectal cancer
- autosomal dominant primary hypertrophic osteoarthropathy
- Alzheimer disease
- colorectal adenoma
- colorectal adenoma formation
- PHOAR2-enteropathy syndrome
- primary hypertrophic osteoarthropathy
- hematuria
- patent ductus arteriosus
- productive infection by HIV-1
regulates
- lipid
- prostaglandin E2
- prostaglandin
- lactic acid
- 6-keto-prostaglandin F1 alpha
- dinoprost
- prostaglandin D2
- adenosine triphosphate
- 15-keto-13,14-dihydroprostaglandin E2
- thromboxane B2
role in cell
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- Nucleus
- basal membrane
- nuclear matrix
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLCO2A1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid transport
- transmembrane transport
- sodium-independent organic anion transport
- prostaglandin transport
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- membrane
- basolateral plasma membrane
- plasma membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- lipid transporter activity
- prostaglandin transmembrane transporter activity
- sodium-independent organic anion transmembrane transporter activity