HMGB4 Gene Summary [Human]
Predicted to enable DNA binding activity, bending. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | HMGB4 |
| Official Name | high mobility group box 4 [Source:HGNC Symbol;Acc:HGNC:24954] |
| Ensembl ID | ENSG00000176256 |
| Bio databases IDs | |
| Aliases | high mobility group box 4 |
| Synonyms | 1700001F22Rik, dJ1007G16.5, high-mobility group box 4, LOC682086 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HMGB4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- high mobility group (HMG)-box domain superfamily
- HMG (high mobility group) box
- HMG-box domain
- high mobility group
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HMGB4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- DNA binding, bending