PNMA1 Gene Summary [Human]
This gene encodes a neuron- and testis-specific protein that is also expressed in some paraneoplastic syndromes affecting the nervous system. Some patients with neurologic disorders develop antibodies against the protein encoded by this gene. The identification of the antineuronal antibodies in the sera of these patients has facilitated the diagnosis of paraneoplastic neurological disorders and the early detection of the associated tumors. [provided by RefSeq, Feb 2014]
Details
| Type | Protein Coding |
| Official Symbol | PNMA1 |
| Official Name | PNMA family member 1 [Source:HGNC Symbol;Acc:HGNC:9158] |
| Ensembl ID | ENSG00000176903 |
| Bio databases IDs | |
| Aliases | PNMA family member 1 |
| Synonyms | 5730402C15Rik, MA1, paraneoplastic antigen MA1, PNMA family member 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PNMA1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PNMA
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PNMA1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response to antigenic stimulus
- positive regulation of apoptotic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein binding