PNMA5 Gene Summary [Human]
This gene encodes a member of the paraneoplastic Ma antigen protein family. These proteins have been implicated in the development of paraneoplastic disorders resulting from an immune response directed against them. Paraneoplastic disorders are the result of an abnormal immune response to a tumor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | PNMA5 |
| Official Name | PNMA family member 5 [Source:HGNC Symbol;Acc:HGNC:18743] |
| Ensembl ID | ENSG00000198883 |
| Bio databases IDs | |
| Aliases | PNMA family member 5, paraneoplastic antigen family 5 |
| Synonyms | Hs.469593, LOC108167389, mKIAA1934, paraneoplastic antigen family 5, PNMA family member 5, RGD1565857 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PNMA5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PNMA
- protein binding
- identical protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- cell cortex
- Nucleus
- meiotic spindles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PNMA5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of apoptotic process
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding