SNRPB2 Gene Summary [Human]

The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
SNRPB2
Official Name
small nuclear ribonucleoprotein polypeptide B2 [Source:HGNC Symbol;Acc:HGNC:11155]
Ensembl ID
ENSG00000125870
Bio databases IDs NCBI: 6629 Ensembl: ENSG00000125870
Aliases small nuclear ribonucleoprotein polypeptide B2
Synonyms 2810052G09Rik, Msl1, small nuclear ribonucleoprotein polypeptide B2, U2-B, U2B'', U2 small nuclear ribonucleoprotein B, U2 SNRNP B''
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SNRPB2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • RNA recognition motif (RRM) superfamily
  • RNA recognition motif
  • ribonucleoprotein binding
  • protein binding

Pathways

Biological processes and signaling networks where the SNRPB2 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
role in cell
  • splicing by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • fibrillar center
  • catalytic step 2 spliceosome
  • cytoplasmic ribonucleoprotein granule
  • intranuclear region
  • spliceosomes
  • nucleoplasm
  • nuclear speckles
  • coiled body
  • perikaryon

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human SNRPB2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • nuclear mRNA splicing, via spliceosome

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • catalytic step 2 spliceosome
  • nuclear speck
  • U2-type catalytic step 2 spliceosome
  • spliceosomal complex
  • U2-type spliceosomal complex
  • U2-type precatalytic spliceosome
  • U2 snRNP
  • U1 snRNP
  • fibrillar center
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • U1 snRNA binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.