TMPRSS9
TMPRSS9 Gene Summary
The protein encoded by this gene is a membrane-bound type II serine polyprotease that is cleaved to release three different proteases. Two of the proteases are active and can be inhibited by serine protease inhibitors, and one is thought to be catalytically inactive. This gene enhances the invasive capability of pancreatic cancer cells and may be involved in cancer progression. [provided by RefSeq, Jul 2016]
Details
| Type | Protein Coding |
| Official Symbol | TMPRSS9 |
| Official Name | transmembrane serine protease 9 [Source:HGNC Symbol;Acc:HGNC:30079] |
| Ensembl ID | ENSG00000178297 |
| Bio databases IDs | |
| Aliases | transmembrane serine protease 9, polyserase 1 |
| Synonyms | POLYSERASE I,Serase-1B,transmembrane protease, serine 9,transmembrane serine protease 9 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- trypsin
- Tryp_SPc
- serine-type peptidase
- peptidase
- serine protease domain
- LDLa
- SEA domain
- Domain of unknown function (DUF1986)
Pathways
Biological processes and signaling networks where the TMPRSS9 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CUL3
- HNRNPH1
disease
- age-related hearing loss
- diabetic nephropathy
- Parkinson disease
- global developmental delay
- weight gain
- hearing loss
- neurotic disorder
regulated by
- SERPINA3
- Serpina1a (includes others)
- SERPINF
- phenylmethylsulfonyl fluoride
- 4-(2-aminoethyl)benzenesulfonylfluoride
regulates
- Boc-Gln-Gly-Arg-AMC
- PLG
- Boc-Gln-Ala-Arg-MCA
role in cell
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the TMPRSS9 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- proteolysis
CELLULAR COMPONENT
Where in the cell the gene product is active
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- serine-type endopeptidase activity