LRRC3B Gene Summary [Human]
The protein encoded by this gene is a tumor suppressor, with lowered expression levels found in gastric, renal, colorectal, lung, and breast cancer tissues. The promoter of this gene is frequently hypermethylated in these cancer tissues, although the hypermethylation does not appear to be the cause of the reduced expression of this gene. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | LRRC3B |
| Official Name | leucine rich repeat containing 3B [Source:HGNC Symbol;Acc:HGNC:28105] |
| Ensembl ID | ENSG00000179796 |
| Bio databases IDs | |
| Aliases | leucine rich repeat containing 3B |
| Synonyms | leucine rich repeat containing 3B, LRP15, RGD1311897 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LRRC3B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine rich repeat
- protein binding
- Leucine rich repeat N-terminal domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LRRC3B gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- extracellular space
- membrane
- extracellular matrix
Molecular Function
What the gene product does at the molecular level
- protein binding