DNPEP Gene Summary [Human]
The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in general metabolism of intracellular proteins. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Details
| Type | Protein Coding |
| Official Symbol | DNPEP |
| Official Name | aspartyl aminopeptidase [Source:HGNC Symbol;Acc:HGNC:2981] |
| Ensembl ID | ENSG00000123992 |
| Bio databases IDs | |
| Aliases | aspartyl aminopeptidase |
| Synonyms | Aspartyl aminopeptidase, ASPEP, DAP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DNPEP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc peptidases M18, M20, M28, and M42
- Aminopeptidase I zinc metalloprotease (M18)
- peptidase
- aminopeptidase
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DNPEP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptide metabolic process
- proteolysis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- blood microparticle
- cytosol
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- identical protein binding
- protein binding
- aminopeptidase activity
- metallopeptidase activity