UBE2S Gene Summary [Human]
This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | UBE2S |
| Official Name | ubiquitin conjugating enzyme E2 S [Source:HGNC Symbol;Acc:HGNC:17895] |
| Ensembl ID | ENSG00000108106 |
| Bio databases IDs | |
| Aliases | ubiquitin conjugating enzyme E2 S, ubiquitin carrier protein, ubiquitin-conjugating enzyme E2-24 kD, ubiquitin-protein ligase |
| Synonyms | 0910001J09Rik, 6720465F12Rik, E2-EPF, E2-EPF5, EPF5, RGD1564746, ubiquitin-conjugating enzyme E2S |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UBE2S often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin-conjugating enzyme
- ubiquitin conjugating enzyme
- binding protein
- ubiquitin-protein transferase activity
- UBCc_UEV
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the UBE2S gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- major depression
- organismal death
- colorectal cancer
- hepatocellular carcinoma
- liver cancer
- uterine serous papillary cancer
- colorectal adenoma
- colorectal adenoma formation
- rotator cuff injury
role in cell
- expression in
- phosphorylation in
- migration
- proliferation
- cytokinesis
- formation
- cell death
- invasion by
- function
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UBE2S gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- protein K11-linked ubiquitination
- protein polyubiquitination
- protein K27-linked ubiquitination
- ubiquitin-dependent protein catabolic process
- cell division
- protein K29-linked ubiquitination
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
- protein K63-linked ubiquitination
- exit from mitosis
- protein K6-linked ubiquitination
- free ubiquitin chain polymerization
Cellular Component
Where in the cell the gene product is active
- nucleus
- anaphase-promoting complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- ubiquitin-protein ligase activity
- protein binding
- anaphase-promoting complex binding