MRGPRX4 Gene Summary [Human]

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within chemosensory behavior and hematopoietic progenitor cell differentiation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

Details

Type
Protein Coding
Official Symbol
MRGPRX4
Official Name
MAS related GPR family member X4 [Source:HGNC Symbol;Acc:HGNC:17617]
Ensembl ID
ENSG00000179817
Bio databases IDs NCBI: 117196 Ensembl: ENSG00000179817
Aliases MAS related GPR family member X4
Synonyms GPCR, MAS related GPR family member X4, MRGX4, SNSR6
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MRGPRX4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • G-protein coupled receptor
  • 7 transmembrane receptor (rhodopsin family)
  • seven-transmembrane G protein-coupled receptor superfamily

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • cancer
  • pruritus
  • colon cancer
regulated by
  • deoxycholate
  • ursodeoxycholic acid
  • taurochenodeoxycholate
  • taurodeoxycholic acid
  • cholic acid
  • oleic acid
  • taurocholic acid
  • chenodeoxycholic acid
role in cell
  • activation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cellular membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human MRGPRX4 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • G-protein coupled receptor signaling pathway

Cellular Component

Where in the cell the gene product is active
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • G-protein coupled receptor activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.