DNAJB4 Gene Summary [Human]
The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Details
| Type | Processed Transcript |
| Official Symbol | DNAJB4 |
| Official Name | DnaJ heat shock protein family (Hsp40) member B4 [Source:HGNC Symbol;Acc:HGNC:14886] |
| Ensembl ID | ENSG00000162616 |
| Bio databases IDs | |
| Aliases | DnaJ heat shock protein family (Hsp40) member B4 |
| Synonyms | 1700029A20Rik, 2010306G19RIK, 5730460G06RIK, CMYO21, CMYP21, DjB4, DnaJ heat shock protein family (Hsp40) member B4, DNAJW, HLJ1, LOC100359900 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DNAJB4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DnaJ domain
- ATPase stimulator
- chaperone protein DnaJ
- DnaJ
- DnaJ molecular chaperone homology domain
- DnaJ C terminal domain
- protein binding
- chaperone binding
Pathways
Biological processes and signaling networks where the DNAJB4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congestive heart failure
- obesity
- weight gain
- non-small cell lung cancer
- organismal death
- lung adenocarcinoma
- lung adenocarcinoma formation
- cutaneous melanoma
- cutaneous melanoma cancer
- peripheral arterial disease
role in cell
- proliferation
- growth
- phosphorylation in
- invasion by
- binding in
- cell cycle progression
- motility
- tumorigenicity
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
- nucleoli
- Z line
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DNAJB4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- response to heat
- chaperone mediated protein folding requiring cofactor
- response to unfolded protein
Cellular Component
Where in the cell the gene product is active
- Z disc
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- chaperone binding
- unfolded protein binding
- ATPase activator activity