ANKRD13D Gene Summary [Human]
The protein encoded by this gene is a member of the ankyrin repeat domain (ANKRD) 13 family, which currently consists of four proteins containing ubiquitin-interacting motifs. These proteins are integral membrane proteins that bind specifically to Lys-63-linked ubiquitin chains on membrane-bound proteins, targeting those proteins for rapid internalization. [provided by RefSeq, Dec 2016]
Details
| Type | Retained Intron |
| Official Symbol | ANKRD13D |
| Official Name | ankyrin repeat domain 13D [Source:HGNC Symbol;Acc:HGNC:27880] |
| Ensembl ID | ENSG00000172932 |
| Bio databases IDs | |
| Aliases | ankyrin repeat domain 13D |
| Synonyms | 0710001P18RIK, AI430801, ankyrin repeat domain 13D, ankyrin repeat domain 13 family, member D, RGD1309156 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ANKRD13D often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ankyrin repeats (many copies)
- protein binding activity, bridging
- Ankyrin repeats (3 copies)
- protein binding
- GPCR-chaperone
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- perinuclear region
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ANKRD13D gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of receptor internalization
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytoplasm
- late endosome
- plasma membrane