DEFB119 Gene Summary [Human]
This gene encodes a member of the beta subfamily of defensins. Beta-defensins are antimicrobial peptides that protect tissues and organs from infection by a variety of microorganisms. This gene is found in a cluster with other beta-defensin genes on the long arm of chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
Details
| Type | Processed Transcript |
| Official Symbol | DEFB119 |
| Official Name | defensin beta 119 [Source:HGNC Symbol;Acc:HGNC:18099] |
| Ensembl ID | ENSG00000180483 |
| Bio databases IDs | |
| Aliases | defensin beta 119 |
| Synonyms | BD-19, Beta-defensin 19, DEFB120, DEFB-19, DEFB-20, Defb24, defensin beta 119, defensin beta 19, defensin beta 24, defensin β 119, defensin β 19, defensin β 24, ESC42-RELA, ESC42-RELB, mBD-19, Tdl, β-defensin 19 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DEFB119 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Beta defensin
- lipopolysaccharide binding
Pathways
Biological processes and signaling networks where the DEFB119 gene in human plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DEFB119 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- defense response to Gram-negative bacterium
- defense response to Gram-positive bacterium
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- lipopolysaccharide binding