ARSJ Gene Summary [Human]
Sulfatases (EC 3.1.5.6), such as ARSJ, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | ARSJ |
| Official Name | arylsulfatase family member J [Source:HGNC Symbol;Acc:HGNC:26286] |
| Ensembl ID | ENSG00000180801 |
| Bio databases IDs | |
| Aliases | arylsulfatase family member J |
| Synonyms | 9330196J05RIK, arylsulfatase family member J, arylsulfatase family, member J, arylsulfatase J, ASJ, D830047F08, LOC102723905, RGD1307640, SULF4, sulph4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARSJ often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alkaline phosphatases and sulfatases
- Sulfatase
- enzyme
- arylsulfatase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- actin cytoskeleton
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARSJ gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- actin cytoskeleton
- extracellular region
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- arylsulfatase activity