ZMIZ2 Gene Summary [Human]
ZMIZ2 and ZMIZ1 (MIM 607159) are members of a PIAS (see MIM 603566)-like family of proteins that interact with nuclear hormone receptors. ZMIZ2 interacts with androgen receptor (AR; MIM 313700) and enhances AR-mediated transcription (Huang et al., 2005 [PubMed 16051670]).[supplied by OMIM, May 2010]
Details
| Type | Protein Coding |
| Official Symbol | ZMIZ2 |
| Official Name | zinc finger MIZ-type containing 2 [Source:HGNC Symbol;Acc:HGNC:22229] |
| Ensembl ID | ENSG00000122515 |
| Bio databases IDs | |
| Aliases | zinc finger MIZ-type containing 2 |
| Synonyms | hZIMP7, LOC103693776, NET27, RGD1309256, TRAFIP20, ZIMP7, zinc finger MIZ-type containing 2, zinc finger, MIZ-type containing 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZMIZ2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- MIZ/SP-RING zinc finger
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- pervasive developmental disorder
role in cell
- growth
- expression in
- proliferation
- phosphorylation in
- invasion by
- migration
- cell cycle progression
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Mitochondria
- nucleoplasm
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZMIZ2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein sumoylation
- SMAD protein signal transduction
- transforming growth factor beta receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- nuclear replication fork
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- ligand-dependent nuclear receptor transcription coactivator activity