CCL13 Gene Summary [Human]
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. [provided by RefSeq, Sep 2014]
Details
| Type | Protein Coding |
| Official Symbol | CCL13 |
| Official Name | C-C motif chemokine ligand 13 [Source:HGNC Symbol;Acc:HGNC:10611] |
| Ensembl ID | ENSG00000181374 |
| Bio databases IDs | |
| Aliases | C-C motif chemokine ligand 13 |
| Synonyms | C-C motif chemokine ligand 13, CKb10, MCP-4, NCC-1, SCYA13, SCYL1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CCL13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemokine
- chemokine receptor binding domain
- Small cytokines (intecrine/chemokine), interleukin-8 like
- protein binding
- receptor binding
- cytokine
Pathways
Biological processes and signaling networks where the CCL13 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- glioma formation
- asthma
- atopic dermatitis
- diabetic nephropathy
- glioma
- systemic sclerosis
- colorectal cancer
- limited cutaneous systemic sclerosis
- androgenic alopecia
role in cell
- activation in
- production in
- proliferation
- activation
- chemotaxis
- shape change
- stimulation
- organization
- binding
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CCL13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- cytoskeleton organization
- signal transduction
- cell-cell signaling
- positive regulation of GTPase activity
- cellular calcium ion homeostasis
- chemotaxis
- inflammatory response
- eosinophil chemotaxis
- chemokine-mediated signaling pathway
- killing of cells of other organism
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- CCR chemokine receptor binding
- chemokine activity
- receptor binding