CXCL11 Gene Summary [Human]
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
Details
| Type | Protein Coding |
| Official Symbol | CXCL11 |
| Official Name | C-X-C motif chemokine ligand 11 [Source:HGNC Symbol;Acc:HGNC:10638] |
| Ensembl ID | ENSG00000169248 |
| Bio databases IDs | |
| Aliases | C-X-C motif chemokine ligand 11 |
| Synonyms | b-R1, C-X-C motif chemokine ligand 11, H174, IFN STIMULATED T-CELL alpha CHEMOATTRACTANT precursor, IFN STIMULATED T-CELL α CHEMOATTRACTANT precursor, IP-9, I-TAC, SCYB11, SCYB9B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CXCL11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- chemokine receptor binding
- CXCR3 chemokine receptor binding
- protein binding
- cytokine
- heparin binding
Pathways
Biological processes and signaling networks where the CXCL11 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- obesity
- COVID-19
- dermatomyositis
- chronic obstructive pulmonary disease
- alopecia areata
- pruritus
- systemic lupus erythematosus
- diffuse cutaneous systemic sclerosis
role in cell
- expression in
- proliferation
- binding in
- activation in
- recruitment
- migration
- loss
- survival
- motility
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CXCL11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- inflammatory response
- T cell chemotaxis
- cellular response to lipopolysaccharide
- signal transduction
- chemokine-mediated signaling pathway
- cell-cell signaling
- neutrophil chemotaxis
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- positive regulation of release of sequestered calcium ion into cytosol
- regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- CXCR chemokine receptor binding
- heparin binding
- CXCR3 chemokine receptor binding
- chemokine activity