NPM1 Gene Summary [Human]
The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017]
Details
| Type | Protein Coding |
| Official Symbol | NPM1 |
| Official Name | nucleophosmin 1 [Source:HGNC Symbol;Acc:HGNC:7910] |
| Ensembl ID | ENSG00000181163 |
| Bio databases IDs | |
| Aliases | nucleophosmin 1, nucleolar phosphoprotein B23, numatrin, nucleophosmin/nucleoplasmin family, member 1 |
| Synonyms | B23, B23.1, B23NP, NO38, NPM, Nucleolar protein B23.2, NUCLEOPHOSMIN, nucleophosmin 1, NUMATRIN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NPM1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- G1 cyclin dependent kinase site
- transcription co-activator
- Nucleophosmin C-terminal domain
- ATP binding
- transcription factor binding
- identical protein binding
- nucleotide-binding domain
- phosphatidylinositol-3,4,5-triphosphate binding
- homodimerization domain
- nucleic acid binding domain
- nucleolar targeting motif
- ribosomal large subunit binding
- ribosomal small subunit binding
- histone binding
- dimerization domain
- protein kinase binding
- nuclear export signal
- rRNA binding
- nucleic acid binding
- oligomerization domain
- protein kinase inhibitor activity
- NF-kappaB binding
- nuclear localization sequence
- enzyme binding
- protein binding
- p53 binding
- sequence-specific DNA binding
- acidic domain
- DNA binding
- RNA binding
- phosphorylation site
- double-stranded DNA binding
- protein homodimerization
- heterodimerization domain
- Nucleoplasmin-like domain
- GSGP loop motif
- basic aromatic repeat
Pathways
Biological processes and signaling networks where the NPM1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- epithelial cancer
- organismal death
- tumor
- glioblastoma
- glioblastoma cancer
- acute myeloid leukemia
- hepatitis C virus-related hepatocellular carcinoma
- liver cancer
role in cell
- proliferation
- expression in
- cell death
- apoptosis
- differentiation
- disruption in
- phosphorylation in
- binding in
- quantity
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- polyribosome fractions
- detergent resistant lipid raft fraction
- Cytoplasm
- nucleolar region
- perichromosomal region
- cell surface
- intracellular space
- ribosome
- centrosome
- polysomes
- granules
- cytosol
- granular components
- chromosome
- prenucleolar bodies
- nucleoplasm
- nucleolus derived foci
- nucleoli
- spindle pole
- nuclear speckles
- nuclear matrix
- centrosomal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NPM1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- regulation of endodeoxyribonuclease activity
- positive regulation of translation
- centrosome cycle
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- cellular senescence
- protein localization
- ribosome assembly
- regulation of centriole replication
- positive regulation of transcription from RNA polymerase II promoter
- intracellular protein transport
- positive regulation of NF-kappaB transcription factor activity
- nucleocytoplasmic transport
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- cellular response to UV
- signal transduction
- negative regulation of protein kinase activity by regulation of protein phosphorylation
- regulation of eIF2 alpha phosphorylation by dsRNA
- nucleosome assembly
- regulation of endoribonuclease activity
- ribosomal small subunit export from nucleus
- ribosomal large subunit export from nucleus
- regulation of centrosome duplication
- ribosomal large subunit biogenesis
- negative regulation of apoptotic process
- negative regulation of centrosome duplication
- ribosomal small subunit biogenesis
Cellular Component
Where in the cell the gene product is active
- nucleolus
- nucleoplasm
- granular component
- spindle pole centrosome
- nucleus
- centrosome
- focal adhesion
- cytoplasm
- membrane
- protein-DNA complex
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein homodimerization activity
- ribosomal small subunit binding
- ribosomal large subunit binding
- unfolded protein binding
- chromatin binding
- protein kinase inhibitor activity
- NF-kappaB binding
- core promoter sequence-specific DNA binding
- protein binding
- RNA binding
- transcription coactivator activity
- histone binding
- Tat protein binding
- rRNA binding