FTMT Gene Summary [Human]
Predicted to enable ferric iron binding activity and ferrous iron binding activity. Involved in several processes, including cellular iron ion homeostasis; positive regulation of aconitate hydratase activity; and positive regulation of succinate dehydrogenase activity. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | FTMT |
| Official Name | ferritin mitochondrial [Source:HGNC Symbol;Acc:HGNC:17345] |
| Ensembl ID | ENSG00000181867 |
| Bio databases IDs | |
| Aliases | ferritin mitochondrial |
| Synonyms | 4930447C24Rik, FerH, ferritin mitochondrial, Fth3, MTF |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FTMT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ferritin-like domain
- iron ion binding
- enzyme
- ferroxidase
- Ferritin-like superfamily of diiron-containing four-helix-bundle proteins
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial fraction
- Mitochondria
- granules
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FTMT gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
- iron ion transport
- positive regulation of cell proliferation
- intracellular sequestering of iron ion
- positive regulation of lyase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial matrix
- cytoplasm
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- ferric iron binding
- ferrous iron binding
- iron ion binding
- ferroxidase activity