NCOA4 Gene Summary [Human]
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]
Details
| Type | Protein Coding |
| Official Symbol | NCOA4 |
| Official Name | nuclear receptor coactivator 4 [Source:HGNC Symbol;Acc:HGNC:7671] |
| Ensembl ID | ENSG00000266412 |
| Bio databases IDs | |
| Aliases | nuclear receptor coactivator 4, RET-activating gene ELE1 |
| Synonyms | 1110034E15RIK, 70 kDa AR-activator, ARA70, ARA70N, ELE1, ELE1 alpha, ELE1 α, nuclear receptor coactivator 4, PTC3, RFG |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NCOA4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- transcription regulator
- LXXLL motif
- transcription co-activator
- B-Box C-terminal domain
- AF-1 domain
- DNA binding domain
- fxxlf motif
- coiled-coil domain
- Nuclear coactivator
- protein binding
Pathways
Biological processes and signaling networks where the NCOA4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- prostate cancer
- rheumatoid arthritis
- colorectal cancer
- neoplastic cell transformation
- osteoarthritis
- diabetic nephropathy
- iron overload
- anemia
role in cell
- phosphorylation in
- apoptosis
- expression in
- proliferation
- differentiation
- cell death
- invasion
- replicative senescence
- growth
- dispersion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- membrane fraction
- detergent resistant lipid raft fraction
- Cytoplasm
- nucleoplasm
- autolysosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NCOA4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to testosterone stimulus
- cellular iron ion homeostasis
- male gonad development
- positive regulation of transcription, DNA-dependent
- protein targeting to lysosome
- response to hormone stimulus
- intracellular estrogen receptor signaling pathway
- cellular response to estrogen stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- transcription coactivator activity