IST1 Gene Summary [Human]
This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Details
| Type | Protein Coding |
| Official Symbol | IST1 |
| Official Name | IST1 factor associated with ESCRT-III [Source:HGNC Symbol;Acc:HGNC:28977] |
| Ensembl ID | ENSG00000182149 |
| Bio databases IDs | |
| Aliases | IST1 factor associated with ESCRT-III, IST1, endosomal sorting complex required for transport-III component |
| Synonyms | 2400003C14Rik, CHMP8, increased sodium tolerance 1 homolog (yeast), IST1 factor associated with ESCRT-III, KIAA0174, mKIAA0174, OLC1, RGD1307799 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IST1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulator of Vps4 activity in the MVB pathway
- binding protein
- MIT interacting motif
- protein domain specific binding
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- azurophil granule lumen
- Extracellular Space
- centrosome
- midbody
- Flemming body
- microtubule organizing centers
- ER-to-Golgi intermediate compartment
- cytosol
- chromatin
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IST1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- establishment of protein localization
- positive regulation of collateral sprouting
- cell division
- abscission
- release of virus from host
- protein transport
- protein localization
- collateral sprouting
- positive regulation of proteolysis
- viral capsid re-envelopment
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- centrosome
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- cytosol
- endoplasmic reticulum-Golgi intermediate compartment
- midbody
- extracellular region
- chromatin
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- cadherin binding