CHMP4B

CHMP4B Gene Summary

This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.[provided by RefSeq, Oct 2009]

Details

Type
Protein Coding
Official Symbol
CHMP4B
Official Name
charged multivesicular body protein 4B [Source:HGNC Symbol;Acc:HGNC:16171]
Ensembl ID
ENSG00000101421
Bio databases IDs NCBI: 128866 Ensembl: ENSG00000101421
Aliases charged multivesicular body protein 4B
Synonyms
2010012F05RIK,C20orf178,C76846,charged multivesicular body protein 4B,CHMP4A,CTPP3,CTRCT31,dJ553F4.4,LOC683288,RGD1309846,RGD1565889,Shax1,SNF7,SNF7-2,Vps32-2,VPS32B
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • PTZ00464
  • protein homodimerization
  • protein binding
  • identical protein binding
  • Snf7

Pathways

Biological processes and signaling networks where the CHMP4B gene plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • NAP1L1
  • RACGAP1
  • RPL7A
  • MRPL14
  • RPL5
  • SNRPB
  • RPS4X
  • NCL
  • FLOT1
  • TUFM
disease
  • cancer
  • melanoma
  • melanoma cancer
  • androgenic alopecia
  • non-insulin-dependent diabetes mellitus
  • posterior polar cataract 31
  • periodontitis
  • multiple types cataract 31
  • dysphagia
  • non-melanoma skin cancer
regulated by
  • WWP2
  • RYR1
  • GJA8
  • RGS2
  • SNCA
  • ARRDC3
  • GSK2578215A
  • LRRK2
  • INHBA
  • leucyl-leucine-methyl ester
regulates
  • fatty acid
  • KCNN4
  • SNCA
  • CHMP7
role in cell
  • loss
  • duplication
  • reassembly
  • cell death
  • organization
  • repair
  • quantity
  • autophagy by
  • assembly
  • replication in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • detergent resistant lipid raft fraction
  • glutaminergic synapse
  • constriction sites
  • perinuclear region
  • cellular membrane
  • Nucleus
  • Plasma Membrane
  • endosomes
  • vesicles
  • midbody
  • cytosol
  • cytoplasmic face of plasma membrane
  • lysosome membrane
  • endosomal membrane
  • nuclear pores
  • nuclear envelope
  • synaptosomes
  • autophagic vacuoles
  • multivesicular bodies
  • kinetochore microtubule
  • gap junction plaques
  • kinetochores
  • postsynaptic density
  • exosomes

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the CHMP4B gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • membrane fission
  • protein transport
  • non-lytic virus budding
  • nucleus organization
  • posttranslational protein targeting to membrane
  • protein polymerization
  • membrane budding
  • non-lytic virus budding from plasma membrane
  • regulation of centrosome duplication
  • plasma membrane repair
  • ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
  • cytokinesis after mitosis
  • autophagy
  • regulation of autophagy
  • multivesicular body sorting pathway
  • exit from mitosis
  • nuclear envelope reassembly
  • mitotic metaphase plate congression
  • neurological system process
  • late endosome to vacuole transport via multivesicular body sorting pathway
  • macroautophagy
  • vesicle fusion with vacuole

CELLULAR COMPONENT

Where in the cell the gene product is active
  • ESCRT III complex
  • kinetochore
  • multivesicular body
  • lysosomal membrane
  • autophagic vacuole membrane
  • plasma membrane
  • internal side of plasma membrane
  • nuclear pore
  • nuclear envelope
  • membrane coat
  • nucleus
  • endosome
  • extracellular vesicular exosome
  • cytoplasm
  • kinetochore microtubule
  • cytosol
  • vesicle
  • multivesicular body membrane
  • midbody

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • identical protein binding
  • protein homodimerization activity
  • protein binding
  • cadherin binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.