DDX53 Gene Summary [Human]
This intronless gene encodes a protein which contains several domains found in members of the DEAD-box helicase protein family. Other members of this protein family participate in ATP-dependent RNA unwinding. [provided by RefSeq, Sep 2011]
Details
| Type | Protein Coding |
| Official Symbol | DDX53 |
| Official Name | DEAD-box helicase 53 [Source:HGNC Symbol;Acc:HGNC:20083] |
| Ensembl ID | ENSG00000184735 |
| Bio databases IDs | |
| Aliases | DEAD-box helicase 53, cancer associated gene, cancer/testis antigen 26 |
| Synonyms | CAGE, CT26, DEAD-box helicase 53 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DDX53 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- K homology (KH) RNA-binding domain, type I
- KH domain
- helicase superfamily c-terminal domain
- DEAD/DEAH box helicase
- N-terminal helicase domain of the DEAD-box helicase superfamily
- protein binding
- DEAD-like helicases superfamily
- K homology RNA-binding domain
- Helicase conserved C-terminal domain
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DDX53 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- RNA helicase activity
- mRNA binding