NT5C1B Gene Summary [Human]

Cytosolic 5-prime nucleotidases, such as NT5C1B, catalyze production of adenosine, which regulates diverse physiologic processes (Sala-Newby and Newby, 2001 [PubMed 11690631]).[supplied by OMIM, Mar 2008]

Details

Type
Protein Coding
Official Symbol
NT5C1B
Official Name
5'-nucleotidase, cytosolic IB [Source:HGNC Symbol;Acc:HGNC:17818]
Ensembl ID
ENSG00000185013
Bio databases IDs NCBI: 93034 Ensembl: ENSG00000185013
Aliases 5'-nucleotidase, cytosolic IB
Synonyms 4921514H13Rik, 5'-nucleotidase, cytosolic IB, AIRP, CN1B, CN-IB, Rdh14
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NT5C1B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • 5'-nucleotidase
  • phosphatase

Pathways

Biological processes and signaling networks where the NT5C1B gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • corneal neovascularization
regulates
  • AMP
  • nucleoside
  • adenosine
  • allantoin
  • purine nucleotide
role in cell
  • cell death

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • cytosol

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human NT5C1B gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • adenosine metabolic process
  • purine nucleotide catabolic process

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • cytosol

Molecular Function

What the gene product does at the molecular level
  • nucleotide binding
  • magnesium ion binding
  • 5'-nucleotidase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.