ARL15 Gene Summary [Human]
Predicted to enable GTP binding activity and GTPase activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ARL15 |
| Official Name | ADP ribosylation factor like GTPase 15 [Source:HGNC Symbol;Acc:HGNC:25945] |
| Ensembl ID | ENSG00000185305 |
| Bio databases IDs | |
| Aliases | ADP ribosylation factor like GTPase 15 |
| Synonyms | A430036I03, ADP-ribosylation factor-like 15, ARF like GTPase 15, ARFRP2, C230032K13Rik, LOC684187 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARL15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sar1p-like members of the Ras-family of small GTPases
- ADP-ribosylation factor family
- ATPase family associated with various cellular activities (AAA)
- Signal recognition particle receptor beta subunit
- Rab subfamily of small GTPases
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- migraines
- non-insulin-dependent diabetes mellitus
- rheumatoid arthritis
- cardiovascular disorder
- coronary artery disease
- metabolic syndrome X
- gout
- nonalcoholic fatty liver disease
- diabetes mellitus
- albuminuria
regulated by
- lipopolysaccharide
- topotecan
- CREB1
- mir-802
regulates
role in cell
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARL15 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity